Package Website: SpatialPCA Tutorial
Overview
SpatialPCA is a spatially aware dimension reduction method that aims to infer a low dimensional representation of the gene expression data in spatial transcriptomics. SpatialPCA builds upon the probabilistic version of PCA, incorporates localization information as additional input, and uses a kernel matrix to explicitly model the spatial correlation structure across tissue locations.
Paper
Paper: Spatially Aware Dimension Reduction for Spatial Transcriptomics, Nature Communications, 2022 https://www.nature.com/articles/s41467-022-34879-1
Tutorial of SpatialPCA
Analysis Codes
Simulation
DLPFC dataset
Slide-Seq mouse cerebellum dataset
Slide-Seq V2 mouse hippocampus dataset
Human breast cancer ST dataset
MOSTA dataset